Research & Innovation For Drug Discovery & Translational Research

by Liz Seyi Digital marketing manager

Our team develops translational strategies to enable smooth transition of candidate molecules into the clinic. We design and perform in vitro studies on primary human cells and ex vivo assays on fresh human biological samples, thanks to our collaboration with a network of clinical hospital centers nearby. Patients’ samples are managed in line with the highest standards for acquisition, transfer and disposal of human biological material. The proximity of hospitals we work with allows us to process the samples directly after their retrieval, which is important for preservation of tissue viability throughout the experimental process.

Advantages of using patient-derived material for drug discovery process:

Studying disease-relevant targets

Target relevance demonstrated on actual patient samples
Identification of functional consequences of target modulation

De-risking candidate selection

Early identification of compounds which might fail in clinical trials
Redirecting resources to more promising compounds, lowering the risk of the whole drug discovery program

Establishment of an early proof of mechanism in humans
Clinically relevant testing

Working on fresh, non-cryopreserved samples increases the reliability of results
Tissue retains its 3D architecture, allowing for more complex interactions
Fresh, functional human tissues are the closest possible model of how drugs will behave in patients
Patient-derived samples accurately represent the heterogeneity observed in the clinic

Bioanalytical capabilities:

DNA/RNA/protein isolation, qRT-PCR, gene silencing
Western blot, multiplex analysis, HPLC/MS
Flow cytometry, high content imaging, confocal microscopy
Histopathology, immunohistochemistry, in situ hybridization
Clinical biochemistry

Discovery Areas

Selvita provides its clients with effective integrated drug discovery support based on broad capabilities and deep experience in small molecule drug discovery, starting from target validation up to the selection of a clinical candidate. We powerfully execute fully-integrated drug discovery programs combining all of Selvita’s core skills in biology and chemistry or else provide partially-integrated or stand-alone services utilising selected capabilities optimally matched to the specific needs of our clients.

Therapeutic areas

Our goal is to provide efficacious, safe, and differentiated preclinical candidates.

We place a strong emphasis on translational science, focusing on disease-relevant animal models and ex-vivo studies where appropriate from patient samples, with the discovery process driven by expert medicinal chemistry and ADME/PK. Inflammation, infection and oncology are our core expertise, accompanied by experience in additional therapeutic areas.