Sperm DNA Fragmentation-What Does It Stands For?

Infertility has become a problem among both men and women. However many advanced technologies have been developed by which a couple can conceive. Particularly talking about men, sometimes abnormalities arise in their sperm due to which they have to face some problems in having a baby. In order to highlight the rank of their molecular damage present in the sperm, there has been an introduction of sperm DNA fragmentation or SDF. Higher chances of damage in the sperm DNA may lead towards some complications especially if someone is preferring fertility treatments.

The main job of sperm DNA fragmentation is about computing the percentage of the sperm which has been broken in the DNA. The size of a sperm is supposed to be very small for which a requirement of big amount of genetic information is needed from the egg. Another working that sperm DNA fragmentation can handle is about examining the number of breaks and nicks present in the DNA of the sperm.

If somebody wants to go through sperm DNA fragmentation, one thing they need to know is about its cost. Almost Rs. 7,000 to 10,000 will be charged by the provider. The rate chart will depend on the location along with charges of the lab.

There is no particular cause to be found which indicate towards DNA sperm fragmentation. Like it can be due to a habit to smoke, or taking alcohol, recreational drugs, etc. Even an infection, elevated testicular temperature, pyrexia, advanced chronological age, oxidative stress, varicocele, environmental and occupational pollutants can cause some adverse effect to the sperm's health. One more thing that matters is the diet. That's why try to take a healthy meal to avoid different kinds of problems.

There has been an inspection which indicates that the amount of sperm damage observed doesn't associate with the semen parameters always. This shows that even if a man is having normal morphology, motility and sperm count, there are chances to have a large amount of sperm damage.

As we said that different forms of treatments are available to treat conditions linked to men and women. If someone is taking a fertility treatment like IVF and there has been a presence of high sperm DNA fragmentation in men, there can be some chances of low pregnancy success rates and high miscarriages. One of the best things a person needs to perform in order to keep away from such problems is to make some lifestyle modifications. Some healthy practices in life can improve the quality of sperm.

There are various kinds of activities like smoking, infections like sexually transmitted infections, radiation and heat, airborne pollution, biological factors like increase in their age and elevated body mass index, and diseases like diabetes can lead to affect the integrity of sperm DNA.

Our advice to smokers and drinkers will be to quit such activities. These bad practices aren't only bad for the sperm's health, but your overall health will be affected. Instead, there can be an effort of spending time in regular exercises, avoid lower body bathing, wearing loose underwear, managing body weight, etc. Along with these things, oxidative stress has a name to damage sperm DNA. It has been mentioned in a study that those who took antioxidants before participating in fertility treatment like ICSI didn't demonstrate dissimilarity in the fertility rate, embryo morphology or cleavage. However, it has been mentioned that the optimistic outcomes of antioxidant therapy on sperm DNA fragmentation sourced by reactive oxygen types are restricted that shows the damage in the sperm DNA stays high in many patients even after getting the treatment.

One thing has been said about infections of the male genital organs that they can be responsible to cause sperm DNA damage. As we said diet has a major role in the health of sperm, a person must need to take vitamin C and vitamin E based supplements that prove to be productive in male infertility. Things containing zinc and selenium are also helpful in reducing DNA fragmentation. Inflammatory cells produce reactive oxygen varieties which are recognized for causing damage and base modifications in DNA. One fact has been mentioned that the eggs hold some potential to repair the damaged sperm upon fertilization. If a man is suffering from low sperm count or some other issues takes place, there are chances to make his partner pregnant with the help of natural procedure.

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