One-Stop Solution for Anti-Membrane Protein sdAb D

by Vivian C. Content marketing

one-stop solutions to generate high-quality single domain antibodies that can properly recognize the target membrane protein for our customers all over the world.

Recommended Features

embrane receptor proteins relay signals between the cell's internal and external environments.
The molecules and ions across the membrane via transport proteins
Membrane proteins may present enzyme activity, such as oxidoreductase and hydrolase.

Learn more about One-Stop Solution for Anti-Membrane Protein sdAb D»

Review on One-Stop Solution for Anti-Membrane Protein sdAb D

One-Stop Solution for Anti-Membrane Protein sdAb Development
Creative Biolabs is a leading service provider that focuses on single domain antibody (sdAb) discovery and development. Based on our deep understanding of various membrane proteins, our scientists have built up one-stop solutions to generate high-quality single domain antibodies that can properly recognize the target membrane protein for our customers all over the world.

Membrane Protein - A Class of the Most Important & Challenging Targets for Antibody Development
In most cancer diseases, therapeutic targets are cell surface molecules which are predominantly comprised of membrane proteins. Membrane protein is a class of targets that are composed of a wide range of structurally and functionally diverse proteins involved in a variety of important physiological and homeostatic processes, such as:

Membrane receptor proteins relay signals between the cell's internal and external environments.
The molecules and ions across the membrane via transport proteins.
Membrane proteins may present enzyme activity, such as oxidoreductase and hydrolase.
Cell adhesion molecules allow cells to identify each other and interact.
In terms of the ability to activate/block the downstream function or promote the analysis of 3D structure, antibodies that can direct against target membrane proteins have played critical roles as either therapeutic/diagnostic agents or research tools. However, membrane protein is also one of the most challenging targets to generate high-quality antibodies, and the limitations usually include: 1) the challenge of designing and producing properly antigen that can mimic the epitopes of nave membrane proteins; 2) homology issues which may cause immunological tolerance; 3) potential steric issues caused by the multi-pass membrane proteins, in which some epitopes cannot be reached by conventional antibodies.

Developing High-Quality Anti-Membrane Protein sdAb at Creative Biolabs
Fortunately, Creative Bi