Which Is Better Fulvestrant Or Tamoxifen?
by Magicine Pharma Sorafenib Tablets IP 200mgFulvestrant 250 Mg Injection,
also known by its brand name Faslodex, is an estrogen blocker used for the
treatment of advanced breast cancer in postmenopausal women. It interferes with
estrogen production and also degrades its receptors. Fulvestrant
250 Mg Injection blocks the activity of AF1 (activation factor) and
AF2. It exhibits high binding affinity for the receptors and interferes in the
dimerization of receptors which stops their nuclear localization. This leads to
the formation of an unstable complex which degrades quickly and causes degradation
of the receptor.
Tamoxifen
on the other hand is a selective estrogen receptor modulator used in treating
breast cancer in pre- and post-menopausal women. It is said to possess both
estrogen agonist and antagonist properties. Tamoxifen also works by blocking
estrogen binding to its receptor. Tamoxifen
works by blocking the working of AF2 however no effect is shown on AF1 which
could be the possible reason for its agonist properties. This agonistic
property of tamoxifen leads to a lesser success rate of treatments. Fulvestrant
does not possess any estrogen agonist property and also shows more potency in
inhibiting breast tumors. It is also effective against cells that show
resistance to tamoxifen. Tamoxifen is related to many side effects like
vaginitis, and gastrointestinal issues and it also increases the risk of
developing endometrial cancer.
Fulvestrant 250 Mg Injection is
given through the intramuscular route and is either used alone or given in
combination with ribociclib which is a common drug used in breast cancer
treatment.
Side effects of the medication-
·
Redness or swelling in the area injection
is administered
·
Dizziness or weakness
·
Nausea
·
Vomiting
·
Diarrhea
·
Constipation
·
Loss of appetite
·
Breathlessness
·
Sore muscles
·
Joint pain
Buy Online Fulvestrant
250 mg Injection should be administered cautiously to
patients with bleeding disorders, thrombocytopenia, low platelet count, or
patients with anticoagulants
Proper consultation is
advised if administered to -
·
Pregnant women as the dosage might cause
fetal harm.
·
Breastfeeding mothers
·
Patients with decreased platelet count
·
Patients with prior medical conditions
especially liver and kidney infections
The price of Fulvestrant 250 mg Injection ranges from
Rs. 5000 to Rs.34000.
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Created on Aug 10th 2023 02:26. Viewed 114 times.