Silica Gel for Flash Chromatography

by Priya Singh An Impurity Free Chromatography for Higher Yield

Flash chromatography, which is also called as medium pressure chromatography, was developed by Clark Still from Columbia University in the year 1978, as an option to gravity column chromatography. Lesser Silica gel and using Air or Nitrogen to drive the solvent gradient down the column. Lesser amount of solvent, Faster separation, silica are its main advantages.

Flash column chromatography is the quick substances that are helpful for removing or separation of contamination from the raw materials. There are no costly equipment’s required for the removal method so it is the commercial way for getting the best results. There are a lot of different processes involved in the parting of the impurities from the raw materials and the equipment’s are speckled in according to the minerals. The procedure generally requires the cylinder column or glass packed with the appropriate below the absorbent. Silica gel is one of the best for giving the result for removing the impurities from the micron size of 40. When the size of the micron increases, then the process will increase the absorption effect. Silica gel is the best adsorbents for flash chromatography in the solid phase that is packed tightly at the bottom of the glass cylinder so the solution will purify the raw material in the process. The contaminants or unwanted substances are absorbed with the help of silica gel. Therefore, when the product is needed for separating the compound for any further analysis, it will be quite useful for processing the column chromatography.

Benefits of Flash Chromatography:

Silica Gel for Flash Chromatography have its biggest advantages are size of the molecules can be known for separating and purifying the reaction mixture in the fast manner. Therefore, it can act for preparing the intermediate sequence of reactions. The flash column chromatography has many different levels so that there are many pigment bands and absorption particles created for chromatography. The size of the silica gel for Flash Chromatography varies according to the size of the impurities that has to be removed and the size can be minimum for fast recovery of the minerals. The pigment bands are also formed based on the different rates so that it will be quite efficient for separation of the impurities in the best manner. The size of the silica gel products varies in the mesh sizes of Silica Gel 60-120 Mesh, Silica Gel 60-200 Mesh, Silica Gel 70-230 Mesh, Silica Gel 100-200 Mesh and many more.

Applications:

• Separation of fine chemicals.

• Column chromatographic separations, isolation & purifications Process.