Predict Drug-Drug Interactions of Your Test Compound Using CYP Induction Assay

by Iontox Biotechnology IONTOX
It is important to understand the induction potential of your drug candidate for understanding drug safety. CYP induction assays assess the potential for up-regulation of cytochrome P450 enzymes as a typical component of drug-drug interaction (DDI) risk.

Cytochrome P450 proteins are important drug metabolizing enzymes. The assessment of CYP induction for the pharmaceutical industry in response to a drug candidate is a crucial aspect of assessing drug-drug interactions, and evaluating drug safety and efficacy. CYP Induction Assay predicts the potential drug-drug interaction of your test compound.

Cytochrome P450 enzymes are important for the metabolism of several medications. Six out of around 60 enzymes present in this class metabolizes 90 percent of the drugs, with the most essential enzyme being CYP3A4. Genetic variations in the enzymes may affect an individual’s response to usually recommended drug classes, including beta blockers and antidepressants.

When induced by drugs, Cytochrome P450 enzymes ends up in drug-drug interactions which results in unfavorable reactions or therapeutic failures. Thus, it is important to assess the CYP induction potential of a test compound. Primary human hepatocytes are considered as the most acceptable assay system to evaluate the extent of induction of CYP enzymes.

Selectiong a Professional Contract Research Organization (CRO) for CYP Induction Assay

Cytochrome P450 Induction Assay from IONTOX is designed to meet the requirements of the client based on the criteria and recommendations of the FDA guidelines on Drug Interaction Studies.

Key Points About CYP Induction Assay

  • Allows right measurement of CYP1A2, CYP2B6 and CYP3A4 at the protein level.
  • Provides accurate, high quality data with the study based on the criteria and recommendations of the FDA guidelines.
  • The assay can be performed using fresh human primary hepatocytes.
  • The effects of the tested compound or metabolites on subsequent tissues can be assessed by combining CYP induction study with the Human Dynamic Multiple Organ Plate.

Find a reliable Contract Research Organization (CRO) who offers quality drug interaction services and provides guidance and support to clients for the discovery and development of novel drugs. The exposure time for the CYP Induction Assay is generally 72 hours, followed by mRNA and CYP1A2, CYP2B6 and CYP3A4 gene expression level assessment. So, evaluate drug-drug interactions of your test compound using the CYP Induction Assay.

To know more about CYP Induction Assay, visit today.

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About Iontox Biotechnology Junior   IONTOX

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Joined APSense since, March 31st, 2020, From Kalamazoo, MI, United States.

Created on Oct 17th 2020 03:52. Viewed 489 times.


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