Articles

Know How to Predict Drug-Drug Interactions Of Your Test Compound Using CYP Induction Assay

by Iontox Biotechnology IONTOX
Cytochrome P450 proteins are significant drug metabolizing enzymes. For pharmaceutical companies developing new compounds, the evaluation of CYP induction is a critical step in assessing drug safety in regards to transporter interaction.

CYP induction helps reduce drug liability by identifying potential drug-drug interactions that may cause unwanted adverse effects.

Why to Choose CYP Induction Assay?

Cytochrome P450 enzymes are vital for the metabolism of numerous medications. There are approximately 60 enzymes present in this class, six of them metabolize 90 percent of drugs, with the most important enzyme being CYP3A4.

Genetic variations in these enzymes may affect an individual’s response to generally recommended drug classes, including beta blockers and antidepressants.

Cytochrome P450 enzymes can be induced by drugs, resulting in clinically significant drug-drug interactions that can cause unwanted adverse reactions or therapeutic failures. Therefore, it is vital to assess the CYP induction potential of a test compound.

The Cytochrome P450 (CYP) Induction Assay from IONTOX is designed to meet the needs of the client based on the criteria and recommendations of the FDA guidelines on Drug Interaction Studies.

Exposure times for the CYP Induction Assay is usually 72 hours, followed by mRNA and CYP1A2, CYP2B6 and CYP3A4 gene expression level assessment.

Key Points About Cytochrome P450 (CYP) Induction Assay

  • Enables measurement of CYP1A2, CYP2B6 and CYP3A4 at the protein level.
  • Delivers accurate, high quality data with the study based on the criteria and recommendations of the FDA guidelines.

So, assess drug-drug interactions of your test compound using the CYP Induction Assay.

For more information regarding the CYP Induction Assay, visit https://www.iontox.com/cyp-induction-assay/ today.

About Iontox Biotechnology Junior   IONTOX

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Joined APSense since, March 31st, 2020, From Kalamazoo, MI, United States.

Created on Jun 13th 2020 02:43. Viewed 122 times.

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