L-Citrulline Malate Side Effects

by James H. food additives professional

Citrulline is made from ornithine and carbamoyl phosphate in one of the central reactions in the urea cycle. Citrulline is also produced from arginine as a by-product of the reaction catalyzed by NOS family (NOS; EC 1.14.13.39). Citrulline is made from arginine by the enzyme trichohyalin at the inner root sheath and medulla of hair follicles. Arginine is first oxidized into N-hydroxyl-arginine, which is then further oxidized to citrulline concomitant with release of nitric oxide.

General Side Effects

No significant side effects reported.

Suggested Dosage

As L-Citrulline Malate is widely known as safe, there is no limit on dosage of intake. However, we still recommend consumers to consult professionals before using large quantity of L-Citrulline Malate for long period.
* ADI: Acceptable Daily Intake
* MTDI: maximum tolerable daily intake
* Data source: JECFA Database of WHO

Special Groups Precaution

Special groups refer to newborns, children, pregnant and any other applicable vulnerable groups.
There is no evidence that L-Citrulline Malate could have any negative effects on these vulnerable groups. It should be safe to use L-Citrulline Malate in food for newborns and pregnant. However, we still recommend consumers to consult professionals before using large quantity of L-Citrulline Malate for long period in food for newborns or pregnant.

GRAS Affirmation: No

Though L-Citrulline Malate is not on FDA’s GRAS exemption list, it’s still widely accepted as safe food additive in many countries including USA with specific limit on dosage.

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