Which Is Better Fulvestrant Or Tamoxifen?

by Magicine Pharma Sorafenib Tablets IP 200mg

Fulvestrant 250 Mg Injection, also known by its brand name Faslodex, is an estrogen blocker used for the treatment of advanced breast cancer in postmenopausal women. It interferes with estrogen production and also degrades its receptors. Fulvestrant 250 Mg Injection blocks the activity of AF1 (activation factor) and AF2. It exhibits high binding affinity for the receptors and interferes in the dimerization of receptors which stops their nuclear localization. This leads to the formation of an unstable complex which degrades quickly and causes degradation of the receptor.

Tamoxifen on the other hand is a selective estrogen receptor modulator used in treating breast cancer in pre- and post-menopausal women. It is said to possess both estrogen agonist and antagonist properties. Tamoxifen also works by blocking estrogen binding to its receptor. Tamoxifen works by blocking the working of AF2 however no effect is shown on AF1 which could be the possible reason for its agonist properties. This agonistic property of tamoxifen leads to a lesser success rate of treatments. Fulvestrant does not possess any estrogen agonist property and also shows more potency in inhibiting breast tumors. It is also effective against cells that show resistance to tamoxifen. Tamoxifen is related to many side effects like vaginitis, and gastrointestinal issues and it also increases the risk of developing endometrial cancer.

Fulvestrant 250 Mg Injection is given through the intramuscular route and is either used alone or given in combination with ribociclib which is a common drug used in breast cancer treatment.

Side effects of the medication-

· Redness or swelling in the area injection is administered

· Dizziness or weakness

· Nausea

· Vomiting

· Diarrhea

· Constipation

· Loss of appetite

· Breathlessness

· Sore muscles

· Joint pain

Buy Online Fulvestrant 250 mg Injection should be administered cautiously to patients with bleeding disorders, thrombocytopenia, low platelet count, or patients with anticoagulants

Proper consultation is advised if administered to -

· Pregnant women as the dosage might cause fetal harm.

· Breastfeeding mothers

· Patients with decreased platelet count

· Patients with prior medical conditions especially liver and kidney infections

The price of Fulvestrant 250 mg Injection ranges from Rs. 5000 to Rs.34000.