What is Giant Papillary Conjunctivitis?

Giant Papillary Conjunctivitis

For people who wear contact lenses, giant papillary conjunctivitis or GPC is a common cause of itchy and irritated eyes. It is thought to result from an allergic reaction to chemicals absorbed by the contact lens or microscopic deposits that have accumulated on the lens. One chemical that has been found to be associated with GPC is a preservative in many contact lens solutions called thimerosal. Irrigation of the underside of the eyelids has been found to aggravate the condition.

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Symptoms of Giant Papillary Conjunctivitis

Most often, the symptoms of GPC occur while the contact lenses are in place; however, they may persist after removal of the lens from the eye. Commonly, the symptoms are an itchy eye. Redness and irritation may be present. Many persons who are afflicted with GPC notice that their contact lenses seem to ride up on their eyes as though the eyelid were grabbing the lens with each blink.

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Diagnosis of Giant Papillary Conjunctivitis

Large bumps with red, inflamed tissue are usually visible on the underside of the upper eyelid in severe cases of GPC. Milder cases result in smaller bumps.

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These bumps on the underside of the upper eyelid are thought to be the cause of the contact lens riding high on the eye with each blink reflex. In very mild cases where the bumps are not readily visible, the diagnosis is often based on this tendency of the contact lens to ride upon the eye.

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Cure Papillary Conjunctivitis

Changing the type of lenses worn may help. Also, changing contact lens solutions to other types that do not contain thimerosal or other preservatives may help. Prescription eye drops can help alleviate the symptoms, especially the itchy feeling. Follow-up care is important. GPC is difficult to control. 

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