LSD ACID,lysergic diethylamide

Lysergic acid diethylamide (LSD)
INN: Lysergide

2D structural formula and 3D models of LSD
Legal status	AU: S9 (Prohibited) CA: Schedule III DE: Anlage I (Authorized scientific use only) NZ: Class A UK: Class A US: Schedule I UN: Psychotropic Schedule I
Pharmacokinetic data
Bioavailability	71%[6]
Protein binding	Unknown[7]
Metabolism	Liver (CYP450)[6]
Metabolites	2-Oxo-3-hydroxy-LSD[6]
Onset of action	30–40 minutes[8]
Elimination half-life	3.6 hours[6][9]
Duration of action	8–12 hours[10]
Excretion	Kidneys[6][9]

Lysergic acid diethylamide (LSD), also known as acid, is a hallucinogenic drug.^[11] Effects typically include altered thoughts, feelings, and awareness of one's surroundings.^[11] Many users see or hear things that do not exist.^[12] Dilated pupils, increased blood pressure, and increased body temperature are typical.^[13] Effects typically begin within half an hour and can last for up to 12 hours.^[13] It is used mainly as a recreational drug and for spiritual reasons.^[13][14] Contents

• 1Uses
  • 1.1Recreational
  • 1.2Spiritual
  • 1.3Medical
• 2Effects
  • 2.1Physical
  • 2.2Psychological
  • 2.3Sensory

• • 
    
    

    Pink elephant blotters containing LSD

    LSD is commonly used as a recreational drug.^[20]

    Spiritual

    LSD is considered an entheogen because it can catalyze intense spiritual experiences, during which users may feel they have come into contact with a greater spiritual or cosmic order. Users sometimes report out of bodyexperiences. In 1966, Timothy Leary established the League for Spiritual Discovery with LSD as its sacrament.^[21][22] Stanislav Grof has written that religious and mystical experiences observed during LSD sessions appear to be phenomenologically indistinguishable from similar descriptions in the sacred scriptures of the great religions of the world and the texts of ancient civilizations.^[23]

    Medical

    See also: Lysergic acid diethylamide § Research

    LSD currently has no approved uses in medicine.^[24][25] A meta analysis concluded that a single dose was effective at reducing alcohol consumption in alcoholism.^[26]LSD has also been studied in depression, anxiety, and drug dependence, with positive preliminary results.^[27]

    Effects

    

    Some symptoms reported for LSD.^[28][29]

    Physical

    LSD can cause pupil dilation, reduced appetite, and wakefulness. Other physical reactions to LSD are highly variable and nonspecific, some of which may be secondary to the psychological effects of LSD. Among the reported symptoms are numbness, weakness, nausea, hypothermia or hyperthermia, elevated blood sugar, goose bumps, heart rate increase, jaw clenching, perspiration, saliva production, mucus production, hyperreflexia, and tremors.^{[medical citation needed]}

    Psychological

    The most common immediate psychological effects of LSD are visual hallucinations and illusions (colloquially known as "trips"), which can vary greatly depending on how much is used and how the brain responds. Trips usually start within 20–30 minutes of taking LSD by mouth (less if snorted or taken intravenously), peak three to four hours after ingestion, and last up to 12 hours. Negative experiences, referred to as "bad trips", produce intense negative emotions, such as irrational fears and anxiety, panic attacks, paranoia, rapid mood swings, intrusive thoughts of hopelessness, wanting to harm others, and suicidal ideation. It is impossible to predict when a bad trip will occur.^[30][31] Good trips are stimulating and pleasurable, and typically involve feeling as if one is floating, disconnected from reality, feelings of joy or euphoria (sometimes called a "rush"), decreased inhibitions, and the belief that one has extreme mental clarity or superpowers.^[30]