Knowledge of Febrifugine

A quinoline Trazodone alkaloids. Formula C16H19N3O3. Febrifugine anesthetic in the analysis of malaria. As an alive additive Changshan bases β and T three. β- Febrifugine fever, aswell accepted as a abject for Changshan base of the capital alkaloid; Melting point 139 ~ 140 ℃; insoluble, acrid adulterated in water, booze in chloroform, booze or chloroform and ethanol. and - Febrifugine fever, aswell accepted as iso-alkali known; Melting point 129 ~ 130 ℃; Attributes and β- Changshan abject is similar, but beyond solubility in chloroform or acetone. It may be a alloyed bread-and-butter of chloroform and booze abstraction solvent, and isolating febrifugine and recrystallized from booze to be used, the authentic artefact crystallized to access febrifugine.

℃. Changshan acrid three canicule close malaria to be effective, and -, β- and γ - Febrifugine ability of blame adjoin malaria were 1100 and 150 times. Febrifugine bodies accept nausea, airsickness and added ancillary furnishings in bound analytic use. Changshan antimalarial base primarily the aftereffect of diminutive carbonyl and hydroxyl groups may be the piperidine ring on the central clue Plasmodium metal chelate formed easily. can booze the ambience of China Changshan Changshan malaria analysis ancillary furnishings abate reaction.

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