CNGBdb - One of the four biological gene Banks in the world

The National Center for Biotechnology Information (NCBI), located in Bethesda, Maryland, Senator Claude Pepper is aware of the importance of computerized information process method to biomedical research guidance, launched the legislation of The National Biotechnology Information Center (NCBI) establishing on November 4th, 1988. NCBI is a branch of the National Library of Medicine (NLM) at NIH. NLM was chosen because of its experience in creating and maintaining bioinformatics databases, and it can establish an internal research program on computational molecular biology. NCBI’s mission is to develop new informatics technologies to help understand the underlying molecular and genetic processes that control health and disease.

Its mission includes four tasks:

Establish automated systems for the storage and analysis of molecular biology, biochemistry, and genetics;

Conduct research on advanced methods for computer-based information processing for the analysis of the structure and function of important molecules and complexes of biology;

Accelerate the use of databases and software by biotechnology researchers and medical therapists;

Collaborative efforts in the collection of biotechnology information worldwide.

The European Bioinformatics Institute (EMBL-EBI) is a non-profit academic institution dedicated to answering life sciences with informatics. Founded in 1994, the Institute is located in the Weikang Trust Gene Park in southern Cambridge, England, and is part of the European Molecular Biology Laboratory.

The European Bioinformatics Institute provides the scientific community with free bioinformatics resources, promotes basic research, provides training and disseminates cutting-edge technology in the industry. The European Bioinformatics Institute manages and maintains a number of large bioinformatics public databases and creates a variety of tools for researchers to analyze and share information. The European Bioinformatics Institute offers the highest quality research environment, numerous interdisciplinary collaboration opportunities and training courses around the world.

Its main tasks are:

Establish and maintain biological databases for the scientific community, provide free data and bioinformatics services, support the storage and mining of biological data, and promote scientific and technological progress;

Continue to promote the development of biology through basic research in bioinformatics;

Provide bioinformatics training for scientists at all levels;

Supporting the transformation of cutting-edge scientific and technological achievements into industry;

Coordinate the provision of European biological data.

With more than 20 years of experience in bioinformatics research and services, the European Bioinformatics Institute is the European node for the collection and dissemination of biological data and the provision of free bioinformatics services. The Institute maintains the world’s most comprehensive database of molecular biology, many of which are familiar to biologists such as ENA (Nucleic Acid Sequence Database), Ensembl (Genome), ArrayExpress (Gene Expression Data) and more. Based on the original EMBL-Bank nucleic acid sequence database, ENA is the most important nucleic acid sequence resource in Europe.

The DNA Data Bank of Japan (DDBJ) was established in 1984 and is an international DNA database with NCBI’s GenBank and EMBL’s EBI database, exchanging updated data and information every day. DDBJ hosted two international annual conferences – the International DNA Database Consultation Conference and the International DNA Database Collaboration Conference to exchange information with each other, so the data of the three libraries is actually the same.

DDBJ mainly collects DNA sequence information from researchers and assigns its data access number. The source of information is mainly from Japanese research institutions, and it also accepts sequences submitted by other countries. The database serves the majority of researchers through WWW Global Network, anonymous FTP, e-mail or Gopher.

China National GeneBank (CNGBdb) is located in Dapeng New District of Shenzhen. It is the world’s fourth largest national database after the world’s three major databases. It is the first and only national gene bank in China. Compared with the other three gene banks in the world, the national gene bank sample is the largest in terms of scale, storage and accessible data.

Based on the internal data source from “Three Banks and Two Platforms” of CNGB and external data source from NCBI, EBI, DDBJ, etc., and following the data standards of international standard alliance such as INSDC, DataCite, GA4GH, GGBN, ACMG, CNGBdb(China National GeneBank DataBase) builds data structures covering literature, gene, variation, protein, etc., and provides data sharing and application services such as data archive, query and retrieval, and analysis.

The National GeneBank is in the leading position in the world in terms of large biological samples and resource storage, gene sequencing, database construction, gene synthesis, gene editing and industrial applications. It is the world’s largest comprehensive gene bank, in which the sample library has stored more than 10 million samples; the digital platform has an annual output of more than 5Pb; the living library protects and preserves about 300,000 plants, millions of animals, and nearly Millions of microbial living resources.

Source: https://www.bgigene.com/news/do-you-know-the-four-major-biological-gene-banks-in-the-world/

Report this Page