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Clonazepam * (Clonazepamum)
Absences (as a rule, it is not a drug of choice due to side effects and the possibility of addiction); a typical absences, atonic and myoclonic seizures (initial or additional therapy); increased muscle tone, sleep disturbances, panic disorders; epileptic status (parenteral administration) and also buy clonazepam online.
Hypersensitivity, including to other benzodiazepines, angle-closure glaucoma, myasthenia gravis, depression of the respiratory center, severe respiratory failure, severe hepatic and / or renal failure, breast-feeding, up to 18 years of age (with panic disorders).
Pregnancy and lactation
Use during pregnancy and during childbirth is allowed only for strict indications, if the expected effect of therapy exceeds the potential risk to the fetus.
In women taking clonazepam, its cancellation before or during pregnancy is possible only in cases where, in the absence of treatment, epileptic seizures are weak and rare and if the likelihood of epileptic status and withdrawal symptoms is assessed as low. There are reports that taking anticonvulsants during pregnancy by women with epilepsy increases the incidence of birth defects in their children.
The FDA category of action on the fetus is D.
From the nervous system and sensory organs: CNS depression - drowsiness (about 50%) and ataxia (about 30%), in some cases decreasing over time; behavioral disorders (25%), most likely in patients with a history of mental disorders; visual impairment (including blurred vision, nystagmus, diplopia), pathological movements of the eyeballs, aphonia, choreiform twitching, dysarthria, dysdiadochokinesia, headache, hemiparesis.
Some other side effects
Muscle weakness, tremor, dizziness, lethargy, fatigue, disorientation, decreased speed of reactions and concentration; confusion, depression, amnesia, hallucinations, hysteria, insomnia, psychosis, suicidal attempts, paradoxical reactions (acute agitation, irritability, nervousness, aggressive behavior, anxiety, sleep disturbances, nightmares, etc.).
From the cardiovascular system and blood (hematopoiesis, hemostasis): palpitations, anemia, leukopenia, thrombocytopenia, eosinophilia.
On the part of the respiratory system: rhinorrhea, bronchorrhea, respiratory depression (especially with iv administration, in patients with concomitant respiratory tract pathology or at the same time taking other drugs that inhibit breathing).
From the digestive tract: violation of salivation (hypersalivation or dry mouth), sore gums, anorexia / increased appetite, nausea, diarrhea / constipation, encopresis, gastritis, hepatomegaly.
From the skin: transient hair loss, hirsutism.
Allergic reactions: skin rash, swelling of the ankles and face.
Other: fever, muscle pain, increase or decrease in body weight, transient increase in blood levels of ALT and AST, dehydration, lymphadenopathy, dysuria, enuresis, nocturia, urinary retention, and a change in libido.
Addiction, drug dependence, withdrawal and aftereffect syndromes are possible (see "Precautions").
The start of use or the abrupt cancellation of clonazepam in patients with epilepsy or with seizures in history can accelerate the development of seizures or an epileptic state.
A number of studies have shown that approximately 30% of patients receiving anticonvulsant therapy for three months showed a decrease in the anticonvulsant activity of drugs, and in some cases, a dose adjustment allowed this activity to be restored.
The risk of drug dependence increases with the use of large doses and with an increase in the duration of administration, as well as in patients with a history of drug and alcohol dependence.
If it is necessary to discontinue treatment with clonazepam, withdrawal should be carried out gradually, by reducing the dose, to reduce the risk of withdrawal syndrome. In this case, the simultaneous administration of another antiepileptic agent is necessary.
With a sharp cancellation after a long dose or high doses, a withdrawal syndrome occurs, characterized by psychomotor agitation, fear, autonomic disorders, insomnia, and in severe cases - mental disorders.
When treating and counseling women with epilepsy who want to have a baby, the following should be taken into account: do not stop anticonvulsant therapy if drugs are used to prevent seizures, because there is a high probability of developing status epilepticus with concomitant hypoxia and a risk to life.
In some cases, when the severity and frequency of epileptic seizures is such that suggests that canceling therapy does not lead to a serious threat to life, treatment can be canceled before and during pregnancy. It should be borne in mind that even moderate convulsions can harm the embryo / fetus.
With prolonged use of clonazepam in pediatric practice, the risk and benefit should be assessed due to the possibility of adverse adverse effects on the physical and mental development of the child, including delayed (may not occur for several years).
Use with caution in surgical and inpatients, as clonazepam may suppress the cough reflex.
During the treatment with clonazepam, the use of alcoholic beverages is unacceptable. Use with caution simultaneously with drugs that cause CNS depression. With the simultaneous administration of drugs that depress the central nervous system, or alcohol, the likelihood of severe adverse reactions increases.
If paradoxical reactions occur, clonazepam should be discontinued.
With prolonged use, it is necessary to periodically monitor the picture of peripheral blood and liver function.
During treatment with clonazepam and within 3 days after its completion, you should not drive vehicles, and also do work that requires the speed of psychomotor reactions.
Storage conditions for the drug
In a dry, dark place at a temperature of no higher than 25 ° C.
Keep out of the reach of children.
Shelf life of the drug
Created on May 5th 2020 04:25. Viewed 255 times.