An Overview of Peptide Therapeutics and its Contract Manufacturing Market
by Crescendo Global Crescendo Global Leadership hiringThe introduction of insulin therapy in the 1920s, for the treatment of diabetes, marked the beginning of the therapeutic use of peptides. Presently, peptide-based therapeutics represent a prominent class of therapeutic interventions. Currently, many peptide therapeutics are being developed for the treatment of oncological disorders. In fact, in 2018, about 75% of such therapeutic products were estimated to be available for the treatment of different cancer indications, accounting for global sales of more than USD 1 billion. It is worth highlighting that, till date, more than 60 peptide drugs have been approved by the United States Food and Drug Association (USFDA), while more than 400 peptides are presently being in clinical trials.
Such therapeutics, when compared to
recombinant antibodies and protein-based interventions, have been shown to
demonstrate better tissue / cell penetration, owing to their small size and low
immunogenicity. Further, the need for advanced technologies, along with specialized
equipment, have resulted in the outsourcing of the peptide production to the
contract manufacturers. The contract manufacturing market in this domain
features the presence of large contract manufacturing organizations (CMO),
mid-sized CMO and small companies.
The
table below provides the information on the key points of different processes
used for synthesis of peptides.
S. No. |
Type |
Processes |
Specifications |
1 |
Chemical |
Liquid phase synthesis |
§ Used for producing peptides with < 8 amino acids § Easy and inexpensive scale-up § Difficult purification § Not highly automated § Long production cycle § Produces only one product § Requires additional set-up for the protection of
C-terminal of the first amino acid |
2 |
Chemical |
Solid phase synthesis |
§ Used for producing long peptides in small quantities § Easy purification § Expensive purification § Highly automated § Short production cycle § Extra steps are required for linkage and cleavage |
3 |
Chemical |
Hybrid phase synthesis |
§ Combination of solid and solution phase § Initial condensation reaction between two or more suitable peptides
takes place in the solid phase § Synthesis of longer peptides (>50 amino acids) |
3 |
Chemical |
Microwave assisted technology |
§ More effective for the synthesis of difficult-to synthesize peptides § Better peptide yield and purity § Better reproducibility § Faster reaction times § High chances of racemization and dehydration |
4 |
Chemical |
Ligation technology |
§ More effective for the synthesis of long peptides § Uses chemical and enzyme-mediated technologies § High yield § Better chemo selectivity |
5 |
Recombinant |
Recombinant Technology |
§ Used for producing immunogenic or biologically active peptides § Easy introduction of unnatural amino acids § More complicated solubility |
Source: Roots Analysis
A contract manufacturer is a third-party
organization that offers manufacturing related services on a contract basis to
other firms. Typically, a client may approach a contract manufacturing firm
after conducting initial R&D for a product and employ its services to
manufacture the product, usually at larger scales.
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Created on Aug 12th 2020 06:35. Viewed 291 times.