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What medications can cause liver swelling and liver failure ?

by Dr Priya Sharma Healthcare Professional
Dr Priya Sharma Advanced Healthcare Professional
Several medications can potentially cause liver swelling (hepatitis) and, in severe cases, lead to liver failure. It's essential to note that not everyone who takes these medications will experience liver problems, but these drugs have been associated with such adverse effects in some individuals. Some of the medications that can cause liver issues include:
Acetaminophen (Tylenol): Taking high doses of acetaminophen or using it for an extended period can lead to liver damage.
Nonsteroidal anti-inflammatory drugs (NSAIDs): Some NSAIDs, like ibuprofen and naproxen, have been linked to liver injury in rare cases.
Antibiotics: Certain antibiotics, such as isoniazid, nitrofurantoin, and tetracyclines, have been associated with liver problems.
Antifungal medications: Some antifungal drugs, including ketoconazole and fluconazole, may cause liver issues.
Antiepileptic drugs (AEDs): Valproic acid (valproate), carbamazepine, and phenytoin are examples of AEDs that can lead to liver problems.
Statins: These cholesterol-lowering drugs, such as atorvastatin and simvastatin, can cause liver enzyme abnormalities in some individuals.
Methotrexate: Used to treat certain cancers, autoimmune diseases, and psoriasis, methotrexate can cause liver toxicity in some patients.
Antiviral medications: Some antiviral drugs used to treat hepatitis C, such as ribavirin and some protease inhibitors, can have hepatotoxic effects.
Antipsychotic medications: Drugs like haloperidol and chlorpromazine have been associated with liver issues in rare cases.
Antidepressants: While uncommon, certain antidepressants, like amitriptyline and duloxetine, may cause liver problems.
Anabolic steroids: Some bodybuilding or athletic performance-enhancing drugs can lead to liver damage.
You must follow the prescribed dosages and consult with a healthcare professional if you have any concerns about potential side effects, especially those related to the liver. Regular monitoring of liver function may be recommended for individuals taking medications known to have hepatotoxic effects. Additionally, combining multiple medications with the potential for liver toxicity can increase the risk, so healthcare providers should be aware of all the drugs a patient is taking. The worst effect of any medication is liver damage, kidney damage or other side effects like blood pressure disturbances.

Which medicines can cause hepatitis ?

Hepatitis refers to inflammation of the liver, and it can have various causes, including infections (viral hepatitis), autoimmune diseases, and exposure to certain medications and toxins. Some medications have been associated with drug-induced hepatitis. Here are some examples of medications that can potentially cause hepatitis:
Isoniazid: An antibiotic used to treat tuberculosis (TB), isoniazid can cause drug-induced liver injury in some patients.
Nitrofurantoin: This antibiotic used to treat urinary tract infections (UTIs) can, in rare cases, lead to drug-induced hepatitis.
Minocycline: A type of tetracycline antibiotic, minocycline, has been linked to hepatitis in some individuals.
Methotrexate: Used to treat cancer, autoimmune diseases, and severe psoriasis, methotrexate can cause hepatotoxicity.
Amoxicillin-clavulanate: This combination antibiotic has been associated with drug-induced liver injury, particularly in older adults.
Itraconazole: An antifungal medication, itraconazole can sometimes cause liver problems.
Ketoconazole: Another antifungal drug, ketoconazole, has been linked to hepatotoxicity.
Allopurinol: Used to treat gout and kidney stones, allopurinol can rarely cause liver inflammation.
Statins: Cholesterol-lowering drugs like atorvastatin and simvastatin can cause liver enzyme abnormalities in some patients.
Valproic acid (valproate): An anticonvulsant used to treat epilepsy and bipolar disorder, valproic acid can lead to hepatotoxicity.
Azathioprine: An immunosuppressive drug used in organ transplantation and for certain autoimmune diseases, azathioprine can cause drug-induced hepatitis.
Propylthiouracil (PTU) and methimazole: These drugs are used to treat hyperthyroidism and can cause liver problems in some individuals.
There are some best hospitals in Bangalore like Manipal Hospital Sarjapur Road where hepatitis treatment, advanced liver failure treatment, liver cancer treatment, liver cirrhosis treatment and liver transplant treatment is done with great success. You can book an appointment at the hospital to also know about the cost of hepatitis treatment, cost of liver transplant in Bangalore , cost of other liver disease treatment. The doctors here are highly efficient in treatment of liver failure and liver transplant procedure, along with guiding you correctly towards medications dosage after liver transplant surgery.
https://www.logintohealth.com/hospital/bengaluru/manipal-hospital-sarjap...
Jul 29th 2023 14:01

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