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Fifty thousand years back may appear like an eternity, our brains, hormonal agents, and impulses have not changed much at all. Let us consider what occurs when we ate food. You eat a hamburger, piece of pizza, or French fries and your body absorbs the macro nutrients, which are carbs, fats and protein. Anything which you can not digest such as alcohol, fiber, contaminants, and so on gets passed through or is filtered by your liver. You have actually become familiar with measuring the food that we consume in calories, but your body operates just in terms of energy. You store this excess energy as fat if you ate more energy than your body needs.