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The store's employees search flea markets, personal collections, auctions, and antique shows for unique and unusual artifacts. Odd items bought and sold by the shop or featured on the show have included a mummified cat, a Rhesus monkey skull, art made from nail clippings, and a straitjacket.

Celebrities appearing on the show have included Jonathan Davis of the band Korn, Whitey Sterling, singer for the New York band Stiffs, Inc., musician Genesis P-Orridge, actress/comedian Amy Sedaris, artist Ann Hirsch, actress Chloë Sevigny, director Lloyd Kaufman, musician Voltaire and actor/comedian Paul Dinello.

Legendary New York playwright Edgar Oliver appeared on the program, and was shown admiring a straitjacket in promotions for the show. High Pitch Eric from The Howard Stern Show also had a segment appearance on the show where he tested some antique electric equipment.

"I have a hard time trying to communicate with people...skateboarding's a way for me to communicate..." -Mark Gonzales, Professional Skateboarder

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Even though the above quote was written by an athlete, I think it fits the theme of the show quite nicely. "Oddities" is a series that centers around an antique store that buys and sells, just that, oddities. Strange medical equipment, and all other manners of macabre artifacts come into and out of the shop, and that alone is interesting, but what I think makes the show unique, and compulsively watchable are the people both in front of and behind the counter.

The owners are passionate about their work, and it brings them into contact with many people. Whether it be authenticators, hobbyists, buyers or even the occasional lawyer, they're always treated kindly and professionally. They're not just buying and selling, they're communicating their passions.

The show does the same thing. A lesser show would consider some patrons as eccentrics, but this show takes a higher stance and presents them as individuals, not making a point of their uniqueness, but not downplaying it either.

I think the subtext is that, in a way, we're all "Oddities", along with the things we love.