Pharmaceutical solutions and what they are used forby Pooja Late so cut
In the pharmaceutical industry, solutions are one of the many ways to convey therapeutic ingredients to parts of the body that need them. We already know that there are many ways of taking drugs and medications. In the same vein, there are different types of pharmaceutical products. Oral, nasal, ophthalmic, otic, topical, parenteral, and so on.
Pharma solutions are also used as preservatives, buffers, and to add flavouring to liquid dosage forms. Pharma solutions are aqueous solutions. There are different types and groups of pharmaceutical solutions. In the first paragraph, we listed orals as a type of pharmaceutical product. Of all oral solutions, aqueous solutions are the most prevalent. This involves dissolving drugs in water. Preservatives, buffers, and flavourings can be added to the dissolved drug. When preparing a solution, make sure you use purified water or distilled water. Examples of aqueous pharmaceutical solutions are syrups, aqueous acids, aromatic waters, and mucilages.
Syrups usually contain a bit of alcohol (usually about 10%). Also, they are highly concentrated and viscous. Syrups also contain sweeteners that make it easier to swallow or ingest. Similarly, mucilages are thick and viscous. Dispersion of vegetable gums in clean and purified water produces mucilages. Mucilages are used as thickeners and suspending agents too.
Pharma solutions are not heterogeneous mixtures. They are actually homogenous and the chemical components are dispersed molecularly. The dispersion is done in a solvent or a mixture of carefully blended solvents. It is not only the therapeutic agent that is dissolved in a solvent; the excipients are also dissolved too. Excipients can exist in different forms. Examples of excipients are:
· Co-solvents such as alcohol, glycol, glycerine, and propylene
· The vehicle. Most times purified water serves as the vehicle
· Buffers (which are used for regulating the pH value of the solution)
· Antioxidants (examples include butylated hydroxytoluene, butylated hydroxyanisole)
· Preservatives such as boric acid, sorbic acid, borate salts, and phenolics.
· Chemicals for modifying the viscocity of the solution examples include alginic acid, and cellulose derivatives.
What are the advantages of pharmaceutical solutions?
· The taste of a pharmaceutical solution can be masked by adding sweeteners
· It makes it possible for aged people and people that have difficulty swallowing to take drugs and medications.
· Its bioavailability exceeds that of solid dosage forms.
· It tends to respond and react faster in the human body because there is no need for it to be dissolved. It goes through the intestinal glands easily and it is therapeutically fast.
· It is easier to swallow than solid drugs that exist in solid forms.
· It is instantly available for absorption in the gastrointestinal tract.
What are the disadvantages of pharmaceutical solutions?
Some of the disadvantages of pharmaceutical solutions are
· It is easier to experience the bitter taste of a drug if it exists as a solution than in solid form.
· Dosage must be meticulously measured using a volumetric dropper or a tablespoon.
· It is not easy to store pharmaceutical solutions because they are usually bulky.
· Also, it is not easy to ship pharmaceutical solutions.
· The therapeutic efficiency of a pharmaceutical solution is affected by its ability to dissolve in different solvents and aqueous solutions.
Created on Jul 15th 2020 07:05. Viewed 163 times.