L-Citrulline Malate Side Effects
by James H. food additives professionalCitrulline is made from ornithine and carbamoyl phosphate in one of the central reactions in the urea cycle. Citrulline is also produced from arginine as a by-product of the reaction catalyzed by NOS family (NOS; EC 1.14.13.39). Citrulline is made from arginine by the enzyme trichohyalin at the inner root sheath and medulla of hair follicles. Arginine is first oxidized into N-hydroxyl-arginine, which is then further oxidized to citrulline concomitant with release of nitric oxide.
General Side Effects
No significant side effects reported.
Suggested Dosage
As L-Citrulline Malate is widely known as safe, there is no
limit on dosage of intake. However, we still recommend consumers to consult
professionals before using large quantity of L-Citrulline Malate for long
period.
* ADI: Acceptable Daily Intake
* MTDI: maximum tolerable daily intake
* Data source: JECFA Database of WHO
Special Groups Precaution
Special groups refer to newborns, children, pregnant and
any other applicable vulnerable groups.
There is no evidence that L-Citrulline Malate could have any negative effects
on these vulnerable groups. It should be safe to use L-Citrulline Malate in
food for newborns and pregnant. However, we still recommend consumers to
consult professionals before using large quantity of L-Citrulline Malate for
long period in food for newborns or pregnant.
GRAS Affirmation: No
Though L-Citrulline Malate is not on FDA’s GRAS exemption list, it’s still widely accepted as safe food additive in many countries including USA with specific limit on dosage.
- See more at: http://www.yameiaspartame.com/l-citrulline-malate-side-effects
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Created on Dec 31st 1969 18:00. Viewed 0 times.