Facts About Cell Culture Media You May Not Be Aware Of
It’s safe to say that scientific progress of any kind would be inconceivable without cell culture. This research tool is irreplaceable in the fields of biology, biochemistry, and life sciences. Since the earliest days of cell culture, it passed through several stages of evolution. Today, biomedical research depends heavily on new approaches, such as 3D cell culture, tissue engineering, regenerative therapies, and primary cell culture. If you wish to learn more about this particular research tool, this topic will provide.
1. A contaminator: Culture Media Bases tend to get contaminated by several “recognized” contaminants, such as bacteria, viruses, endotoxins, and mycoplasma. However, only a few people know that the plasticizers released by instruments made of plastic can also contaminate cells in culture. Even specific substances present in water can infect the cells and change their behavior.
2. The first successful culturing: The nerve fibers of frogs were the first cells cultured successfully in 1907 by an American zoologist called Ross Granville Harrison. He was able to grow these cells outside the body of a frog. To do it, he leveraged the method called “hanging drop” from bacteriology and used the same with tissue culture. In the end, the scientist managed to reproduce the neuroblasts of frogs in a lymph medium.
3. Absence of recognized original stock: The sphere of life sciences suffers from one relevant problem – using misidentified cell lines. Studies prove that more than 32,000 papers contain results attained from the wrong cells. The story doesn’t end here. About half a million other research documents used these reports for citation. Understandably, this problem with “contaminated” science literature is serious.
4. Failure of reproducing: People from the “Nature” magazine conducted a survey with over 1,500 researchers. The survey found that almost 70% of the participants failed to replicate the results of the experiments conducted by world-renowned scientists. Also, about half of them couldn’t recreate the outcomes of their own experiments.
5. No consent: In 1951, a group of scientists acquired cells from a tumor biopsy of an African-American woman named Henrietta Lacks. Diagnosed with cervical cancer, this lady’s cells were the first human cell line. However, the scientists garnered the cells without informing the patient. Not even her family knew anything about it until 1975. This event led to concerns in the minds of commoners about privacy and the rights of the patients in biomedical research.
6. The creation: In 1950, J.F. Morgan developed Medium 199. It was the first synthetic media used in growing mammalian cells in culture. The concept of designing a chemically defined medium without using animal components made this substance perfect for the production of vaccines.
Endnote
Here’s one more fact for you from Cell Culture Media Manufacturers – the value of the worldwide market of 3D cell culture was about $1 billion in 2016. Market researchers expected it to quadruple in 2021 and that’s what happened. It’s a profound increment of 30% within five years. Several things contribute to the growth of the market, including technological advancements, R&D investments, and improved consumer healthcare accessibility.
1. A contaminator: Culture Media Bases tend to get contaminated by several “recognized” contaminants, such as bacteria, viruses, endotoxins, and mycoplasma. However, only a few people know that the plasticizers released by instruments made of plastic can also contaminate cells in culture. Even specific substances present in water can infect the cells and change their behavior.
2. The first successful culturing: The nerve fibers of frogs were the first cells cultured successfully in 1907 by an American zoologist called Ross Granville Harrison. He was able to grow these cells outside the body of a frog. To do it, he leveraged the method called “hanging drop” from bacteriology and used the same with tissue culture. In the end, the scientist managed to reproduce the neuroblasts of frogs in a lymph medium.
3. Absence of recognized original stock: The sphere of life sciences suffers from one relevant problem – using misidentified cell lines. Studies prove that more than 32,000 papers contain results attained from the wrong cells. The story doesn’t end here. About half a million other research documents used these reports for citation. Understandably, this problem with “contaminated” science literature is serious.
4. Failure of reproducing: People from the “Nature” magazine conducted a survey with over 1,500 researchers. The survey found that almost 70% of the participants failed to replicate the results of the experiments conducted by world-renowned scientists. Also, about half of them couldn’t recreate the outcomes of their own experiments.
5. No consent: In 1951, a group of scientists acquired cells from a tumor biopsy of an African-American woman named Henrietta Lacks. Diagnosed with cervical cancer, this lady’s cells were the first human cell line. However, the scientists garnered the cells without informing the patient. Not even her family knew anything about it until 1975. This event led to concerns in the minds of commoners about privacy and the rights of the patients in biomedical research.
6. The creation: In 1950, J.F. Morgan developed Medium 199. It was the first synthetic media used in growing mammalian cells in culture. The concept of designing a chemically defined medium without using animal components made this substance perfect for the production of vaccines.
Endnote
Here’s one more fact for you from Cell Culture Media Manufacturers – the value of the worldwide market of 3D cell culture was about $1 billion in 2016. Market researchers expected it to quadruple in 2021 and that’s what happened. It’s a profound increment of 30% within five years. Several things contribute to the growth of the market, including technological advancements, R&D investments, and improved consumer healthcare accessibility.
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