Anastrozole in Oligospermia Hyper Androgenic Subfertile Men

by Danish S. MAGICINE PHARMA | SEARCH LATEST MEDS

Anastrozole 1 mg tablet is an aromatase inhibitor used to treat oligospermia or the low production of sperm in hyper androgenic sub fertile men. This condition, also known as male factor infertility, refers to the decreased quantity or quality of male reproductive cells in the semen and affects around 10-15% of couples worldwide. Anastrozole Tablet is an effective alternative to traditional treatments such as glucocorticoids and gonadotropin therapy, as it has been found to improve semen parameters and increase stem cell production.

Anastrozole effective action

Anastrozole dose works by inhibiting the enzyme aromatase, which is responsible for the conversion of androgens (male hormones) to estrogens (female hormones). It is often used as an adjuvant treatment in combination with other anti-androgens, such as ketoconazole and spironolactone, to reduce male sex hormones and improve fertility. By inhibiting aromatase, Anastrozole also reduces the synthesis of estrogens in the testes, resulting in increased testicular size and improved sperm count.

Results from clinical trials

In clinical trials, Anastrozole tablets have been shown to significantly reduce androgen levels in the majority of male patients with oligospermia. A study conducted in 2010 found that men who took Anastrozole for four months experienced an increase in mean sperm concentration from 6 million/mL to 34 million/mL. Another study similarly found an increase in sperm motility, with a mean rise of 13.2%.

Treatment measures and side effects

Further, Anastrozole 1mg Tablet has been found to improve overall fertility rates in hyper androgenic sub fertile men, although exact figures and further studies are needed to confirm this. Anastrozole is also generally considered to have fewer side effects than treatments such as glucocorticoids and gonadotropin therapy. The most common side effects associated with it are nausea, hot flashes and headaches, although these do not usually last long and can generally be reversed if the patient stops taking the drug.

Conclusion

In conclusion, Anastrozole is an effective treatment option for oligospermia in hyper androgenic sub fertile men, with benefits such as increased sperm count, motility and improved overall fertility rates. It is generally well-tolerated, with few side effects, making it an attractive alternative to traditional treatments. However, further research is needed to confirm the full extent of its impact on fertility, as well as its long-term safety.

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