Constipation on Mounjaro or Ozempic: What You Need to Know

Mounjaro (tirzepatide) and Ozempic (semaglutide) are two popular medications for type 2 diabetes and weight loss, but they can come with digestive side effects—including constipation. While these GLP-1 receptor agonists are highly effective, many users experience changes in bowel habits, ranging from mild discomfort to severe constipation.

Why Do Mounjaro and Ozempic Cause Constipation?

Both Mounjaro and Ozempic work by slowing gastric emptying, meaning food stays in the stomach longer. This helps control appetite and blood sugar levels but can also lead to slower digestion and constipation. Other factors contributing to constipation include:

• Reduced Gut Motility: The medications slow down the movement of food through the intestines.
• Decreased Food Intake: Since these drugs suppress appetite, people eat less, which can reduce stool bulk.
• Changes in Gut Microbiome: Some users report altered gut bacteria, which may contribute to digestive discomfort.

How to Relieve Constipation While Taking Mounjaro or Ozempic

If you’re experiencing constipation, here are some ways to find relief:

1. Increase Fiber Intake – Add high-fiber foods like fruits, vegetables, whole grains, and legumes to your diet. If needed, fiber supplements such as psyllium husk can help.
2. Stay Hydrated – Drinking plenty of water can soften stools and ease bowel movements.
3. Exercise Regularly – Physical activity stimulates digestion and helps keep the bowels moving.
4. Use Over-the-Counter Solutions – Stool softeners, magnesium supplements, or mild laxatives may provide relief, but consult your doctor before using them regularly.
5. Adjust Medication Timing or Dosage – If constipation becomes severe, your doctor may recommend adjusting the dose or exploring alternative treatments.

Other Common Ozempic (Semaglutide) Side Effects

While constipation is a notable side effect, Ozempic users may also experience:

• Nausea & Vomiting – The most common digestive complaint, especially at the start of treatment.
• Diarrhea – Some people experience the opposite of constipation due to gut sensitivity.
• Bloating & Gas – A result of slowed digestion.
• Fatigue & Dizziness – Possibly linked to changes in blood sugar levels.

When to See a Doctor

If constipation becomes severe, lasts for more than a week, or is accompanied by intense abdominal pain, nausea, or vomiting, seek medical advice. Chronic constipation can lead to complications like hemorrhoids or fecal impaction.

Final Thoughts

Constipation is a common yet manageable side effect of Mounjaro and Ozempic. By making lifestyle adjustments and staying proactive with gut health, most users can find relief. If symptoms persist, consult your healthcare provider to explore treatment options. Read More About: How Long Does It Take to Lose 15 lbs on Tirzepatide (Zepbound or Mounjaro)?