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Purmorphamine

by Ada Brown PhD
Directly binds and activates Smoothened
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Review on Purmorphamine

Purmorphamine, under the IUPAC name 9-Cyclohexyl-N-[4-(4-morpholinyl)phenyl]-2-(1-naphthalenyloxy)-9H-purin-6-amine, is a cell-permeable 6,9-trisubstituted purine which directly binds and activates Smoothened (in HEK293T cellIC50= ~ 1.5 M ).So it has been shown to activate the Hedgehog (Hh) signaling pathway which is important for regulating embryonic patterning, stem cell renewal, and tissue regeneration. In vitro: An activator of the hedgehog (Hh) signaling pathway by directly binds and activates Smoothened (in HEK293T cellIC50= ~ 1.5 M ). In vivo: Purmorphamine up-regulates ALP expression in human mesenchymal stem cell-based constructs on rats.

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About Ada Brown Freshman   PhD

1 connections, 2 recommendations, 38 honor points.
Joined APSense since, May 25th, 2015, From New York, United States.

Created on Dec 15th 2016 03:00. Viewed 264 times.

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