Articles
A Study Shows That NMN Slows Aging
by Sandra William health is wealthScientists from the St Luis University School of Medicine in Washington (USA) managed to "slow down" the aging of mice by supplying them with a natural compound known as NMN mixed with water.
Much of human health depends on how well the body produces and uses energy. For reasons that are not clear, the ability of cells to produce energy decreases with age, which has led scientists to suspect that the constant loss of efficiency in the body's energy supply chain is a key factor in the process of aging.
Now, according to Tendencias21, scientists from the San Luis University School of Medicine in Washington (USA) have shown that giving healthy mice a supplement of a natural compound called nicotinamide mononucleotide (NMN) can compensate for this loss of production. energy, and thus reduce the typical signs of aging, such as gradual weight gain, loss of insulin sensitivity or decrease in physical activity.
In the study with mice, it was shown that NMN made older mice have a metabolism and energy levels similar to those of younger mice, says Shin-ichiro Imai, one of the authors of the study.
The researchers hope that, given that human cells rely on this same energy production process, the finding will translate into a method to help people stay healthier as they get older.
Imai and his collaborators are already conducting a clinical trial to test the safety of NMN in healthy people. The first phase of the trial began earlier this year at the Keio University School of Medicine in Tokyo.
Previous studies:
With age, the body loses its ability to generate a key element of energy production that is nicotinamide adenine dinucleotide (NAD). In a previous work, Imai and other scientists demonstrated that NAD levels decrease in multiple tissues as mice age.
Previous research had also shown that NAD is not effective when administered directly to mice, so scientists looked for an indirect way to increase their levels. To do this, they only had to look at an earlier step in the NAD production line: the NMN compound.
Measured effects:
To determine the long-term effects of the NMN supply in the body, the scientists studied three groups of healthy mice.
After five months of age, a part of them was given a high dose of drinking water with NMN; to another group a low dose of drinking water with NMN, and a third group served as a control group. These animals were not given any NMN, to compare them with the others.
The comparisons were made every three months from the beginning of the experiment, and until the mice reached 17 months of age (laboratory mice usually live about two years).
The researchers thus found various beneficial effects derived from the NMN supplement in skeletal muscle (by improving the function of mitochondria that operate as cellular power plants); liver function, bone density, ocular function (retinal and improved tear production), insulin sensitivity, immune function, body weight (including increasing the amount of food that mice received) and levels of physical activity. However, these benefits were observed only in older mice.
That is, when NMN was given to young mice, they did not develop into healthy young mice, the scientists explain. The reason is that young mice still produce a lot of NMN on their own.
"We suspect that the increase in the inflammation of aging reduces the ability of the body to make NMN and, by extension, NAD," the scientists say, based on the results obtained.
On the other hand, the study showed that NMN can be administered safely; that supplied dissolved in drinking water appears in the bloodstream in less than three minutes; and once the NMN reaches the blood it rapidly converts to NAD in multiple tissues.
This natural compound is found in foods such as broccoli, cabbage, cucumbers or avocados.
This original content appear here: https://herbalcart.blogspot.com/2018/12/a-study-shows-that-nmn-slows-aging.html
Much of human health depends on how well the body produces and uses energy. For reasons that are not clear, the ability of cells to produce energy decreases with age, which has led scientists to suspect that the constant loss of efficiency in the body's energy supply chain is a key factor in the process of aging.
Now, according to Tendencias21, scientists from the San Luis University School of Medicine in Washington (USA) have shown that giving healthy mice a supplement of a natural compound called nicotinamide mononucleotide (NMN) can compensate for this loss of production. energy, and thus reduce the typical signs of aging, such as gradual weight gain, loss of insulin sensitivity or decrease in physical activity.
In the study with mice, it was shown that NMN made older mice have a metabolism and energy levels similar to those of younger mice, says Shin-ichiro Imai, one of the authors of the study.
The researchers hope that, given that human cells rely on this same energy production process, the finding will translate into a method to help people stay healthier as they get older.
Imai and his collaborators are already conducting a clinical trial to test the safety of NMN in healthy people. The first phase of the trial began earlier this year at the Keio University School of Medicine in Tokyo.
Previous studies:
With age, the body loses its ability to generate a key element of energy production that is nicotinamide adenine dinucleotide (NAD). In a previous work, Imai and other scientists demonstrated that NAD levels decrease in multiple tissues as mice age.
Previous research had also shown that NAD is not effective when administered directly to mice, so scientists looked for an indirect way to increase their levels. To do this, they only had to look at an earlier step in the NAD production line: the NMN compound.
Measured effects:
To determine the long-term effects of the NMN supply in the body, the scientists studied three groups of healthy mice.
After five months of age, a part of them was given a high dose of drinking water with NMN; to another group a low dose of drinking water with NMN, and a third group served as a control group. These animals were not given any NMN, to compare them with the others.
The comparisons were made every three months from the beginning of the experiment, and until the mice reached 17 months of age (laboratory mice usually live about two years).
The researchers thus found various beneficial effects derived from the NMN supplement in skeletal muscle (by improving the function of mitochondria that operate as cellular power plants); liver function, bone density, ocular function (retinal and improved tear production), insulin sensitivity, immune function, body weight (including increasing the amount of food that mice received) and levels of physical activity. However, these benefits were observed only in older mice.
That is, when NMN was given to young mice, they did not develop into healthy young mice, the scientists explain. The reason is that young mice still produce a lot of NMN on their own.
"We suspect that the increase in the inflammation of aging reduces the ability of the body to make NMN and, by extension, NAD," the scientists say, based on the results obtained.
On the other hand, the study showed that NMN can be administered safely; that supplied dissolved in drinking water appears in the bloodstream in less than three minutes; and once the NMN reaches the blood it rapidly converts to NAD in multiple tissues.
This natural compound is found in foods such as broccoli, cabbage, cucumbers or avocados.
This original content appear here: https://herbalcart.blogspot.com/2018/12/a-study-shows-that-nmn-slows-aging.html
Sponsor Ads
About Sandra William 
health is wealth
9 connections, 0 recommendations, 35 honor points.Joined APSense since, June 18th, 2018, From New Port Richey, United States.
Created on Jan 2nd 2019 14:55. Viewed 287 times.
Comments
No comment, be the first to comment.
